CovidV1, Main, Exploration, bibRecord, 000A10

Reservoir Host Immune Responses to Emerging Zoonotic Viruses

Identifieur interne : 000A10 ( Main/Exploration ); précédent : 000A09; suivant : 000A11

Reservoir Host Immune Responses to Emerging Zoonotic Viruses

Auteurs : Judith N. Mandl [États-Unis] ; Rafi Ahmed [États-Unis] ; Luis B. Barreiro [Canada] ; Peter Daszak [États-Unis] ; Jonathan H. Epstein [États-Unis] ; Herbert W. Virgin [États-Unis] ; Mark B. Feinberg [États-Unis]

Source :

Cell [ 0092-8674 ] ; 2014.

RBID : PMC:4390999

Abstract

Zoonotic viruses, such as HIV, Ebola virus, coronaviruses, influenza A viruses, hantaviruses, or henipaviruses, can result in profound pathology in humans. In contrast, populations of the reservoir hosts of zoonotic pathogens often appear to tolerate these infections with little evidence of disease. Why are viruses more dangerous in one species than another? Immunological studies investigating quantitative and qualitative differences in the host-virus equilibrium in animal reservoirs will be key to answering this question, informing new approaches for treating and preventing zoonotic diseases. Integrating an understanding of host immune responses with epidemiological, ecological, and evolutionary insights into viral emergence will shed light on mechanisms that minimize fitness costs associated with viral infection, facilitate transmission to other hosts, and underlie the association of specific reservoir hosts with multiple emerging viruses. Reservoir host studies provide a rich opportunity for elucidating fundamental immunological processes and their underlying genetic basis, in the context of distinct physiological and metabolic constraints that contribute to host resistance and disease tolerance.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390999

DOI: 10.1016/j.cell.2014.12.003
PubMed: 25533784
PubMed Central: 4390999

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">Zoonotic viruses, such as HIV, Ebola virus, coronaviruses, influenza A viruses, hantaviruses, or henipaviruses, can result in profound pathology in humans. In contrast, populations of the reservoir hosts of zoonotic pathogens often appear to tolerate these infections with little evidence of disease. Why are viruses more dangerous in one species than another? Immunological studies investigating quantitative and qualitative differences in the host-virus equilibrium in animal reservoirs will be key to answering this question, informing new approaches for treating and preventing zoonotic diseases. Integrating an understanding of host immune responses with epidemiological, ecological, and evolutionary insights into viral emergence will shed light on mechanisms that minimize fitness costs associated with viral infection, facilitate transmission to other hosts, and underlie the association of specific reservoir hosts with multiple emerging viruses. Reservoir host studies provide a rich opportunity for elucidating fundamental immunological processes and their underlying genetic basis, in the context of distinct physiological and metabolic constraints that contribute to host resistance and disease tolerance.</p>
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Reservoir Host Immune Responses to Emerging Zoonotic Viruses

Reservoir Host Immune Responses to Emerging Zoonotic Viruses

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Abstract

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